Advances in DNA Repair in Cancer Therapy

Advances in DNA Repair in Cancer Therapy

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a€‹A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark qrelapseq or qdrug resistanceq phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.a€‹This DNA damage, if unrepaired, triggers cell death through mitotic catastrophe and apoptosis. ... that initiate and coordinate DNA repair activity by halting the cell cycle through the activation of checkpoints that block cells at the G1-S transition, anbsp;...

Title:Advances in DNA Repair in Cancer Therapy
Author: Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali
Publisher:Springer Science & Business Media - 2012-12-09

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