Proteome Research: Mass Spectrometry

Proteome Research: Mass Spectrometry

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Recent advances in large-scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Two-dimensional gel electrophoresis can be used to create cellular protein maps which give a quantitative and qualitative picture of the proteome. Mass spectrometry is the method of choice for the rapid large-scale idenfification of these proteomes and their modifications. An understanding of these methods is critical for scientists in the qPost-Genomeq era.... Dongarra J, Jiang W, Manchek R, Sunderam V (1994) PVM: Parallel Virtual Machine a usersa#39; guide and tutorial for networked parallel computing. MIT Press, Cambridge Krishna RG, Wold F (1993) Post-translational modification of proteins. ... Conover CA (1999) The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasmaanbsp;...

Title:Proteome Research: Mass Spectrometry
Author: Peter James
Publisher:Springer Science & Business Media - 2001-01-01

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